Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.37 |
| ▸ | AKT1 | P31749 | 4/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28830325 | 0.84 | RAF1 (0.38) | MAPTCYP1A2CYP2D6POLBMEN1 | |
| SCHEMBL28830297 | 0.81 | CYP1A2 (0.43) | MAPTCYP1A2CYP2D6POLBMEN1 | |
| SCHEMBL29762410 | 0.81 | RAF1 (0.47) | MAPTCYP1A2CYP2D6POLBMEN1 | |
| SCHEMBL23274738 | 0.81 | RAF1 (0.47) | MAPTCYP1A2CYP2D6POLBMEN1 | |
| SCHEMBL23274711 | 0.77 | TP53 (0.42) | MAPTCYP1A2CYP2D6POLBMEN1 | |
| SCHEMBL23274715 | 0.77 | TP53 (0.42) | MAPTCYP1A2CYP2D6POLBMEN1 | |
| SCHEMBL28830342 | 0.75 | SLC6A3 (0.35) | — | |
| SCHEMBL23299989 | 0.75 | JAK3 (0.40) | MAPTCYP1A2CYP2D6PIK3CAAKT1 | |
| SCHEMBL23275253 | 0.75 | JAK3 (0.40) | MAPTCYP1A2CYP2D6PIK3CAAKT1 | |
| SCHEMBL29900790 | 0.75 | JAK3 (0.40) | MAPTCYP1A2CYP2D6PIK3CAAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114845711-A | Inhibitors of RAF kinase | 金耐特生物制药公司 | 2022-08-02 | — | — | CN | disclosed |