Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 5/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23299989 | 1.00 | JAK3 (0.40) | JAK3BTKAKT1SUV39H2CKS1B | |
| SCHEMBL23275253 | 1.00 | JAK3 (0.40) | JAK3BTKAKT1SUV39H2CKS1B | |
| SCHEMBL23274715 | 0.86 | TP53 (0.42) | AKT1TP53RAF1BRAFCYP1A2 | |
| SCHEMBL23274711 | 0.86 | TP53 (0.42) | AKT1TP53RAF1BRAFCYP1A2 | |
| SCHEMBL29762501 | 0.83 | GAA (0.41) | JAK3BTKAKT1SUV39H2CKS1B | |
| SCHEMBL23299990 | 0.83 | GAA (0.41) | JAK3BTKAKT1SUV39H2CKS1B | |
| SCHEMBL23275378 | 0.83 | GAA (0.41) | JAK3BTKAKT1SUV39H2CKS1B | |
| SCHEMBL28830325 | 0.80 | RAF1 (0.38) | AKT1RAF1BRAFGAACYP1A2 | |
| SCHEMBL29849723 | 0.78 | EIF2AK4 (0.42) | JAK3BTKSUV39H2CKS1BSKP1 | |
| SCHEMBL28830326 | 0.78 | SLC6A3 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4048259-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-08-31 | — | — | EP | disclosed |