Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | VEGFA | P15692 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30053626 | 1.00 | L3MBTL1 (0.38) | L3MBTL1HTR6ALDH1A1NAMPTCYP3A4 | |
| SCHEMBL23119940 | 0.91 | L3MBTL1 (0.36) | L3MBTL1HTR6ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL23119942 | 0.91 | L3MBTL1 (0.39) | L3MBTL1HTR6ALDH1A1NAMPTCYP3A4 | |
| SCHEMBL23120001 | 0.88 | L3MBTL1 (0.36) | L3MBTL1HTR6ALDH1A1NAMPTPDE5A | |
| SCHEMBL23120054 | 0.88 | L3MBTL1 (0.34) | L3MBTL1HTR6ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL30051724 | 0.86 | L3MBTL1 (0.36) | L3MBTL1HTR6ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL28830396 | 0.86 | L3MBTL1 (0.36) | L3MBTL1HTR6ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL23119964 | 0.86 | L3MBTL1 (0.36) | L3MBTL1HTR6ALDH1A1RAB9AHTT | |
| SCHEMBL31656237 | 0.86 | L3MBTL1 (0.41) | L3MBTL1HTR6ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL29634651 | 0.86 | L3MBTL1 (0.35) | L3MBTL1HTR6ALDH1A1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110724142-B | Amide or sulfonamide substituted hydrazine derivatives as JAK kinase inhibitors | 启元生物(杭州)有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-110724142-A | Amide or sulfonamide substituted hydrazine derivatives as JAK kinase inhibitors | 维眸生物科技（上海）有限公司 | 2020-01-24 | — | — | CN | disclosed |