Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23119939 | 1.00 | CTSK (0.59) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL28830439 | 1.00 | CTSK (0.59) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL31317827 | 0.91 | CA1 (0.59) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL17951138 | 0.91 | CA1 (0.59) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL31317808 | 0.91 | CA1 (0.59) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL21882076 | 0.91 | CTSK (0.55) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL28830425 | 0.87 | CTSK (0.50) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL1959133 | 0.80 | CTSK (0.64) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL428907 | 0.80 | CTSK (0.64) | CTSKCA1CA2HSD11B1CYP2C9 | |
| SCHEMBL359644 | 0.80 | CTSK (0.64) | CTSKCA1CA2HSD11B1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110724142-B | Amide or sulfonamide substituted hydrazine derivatives as JAK kinase inhibitors | 启元生物(杭州)有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-110724142-A | Amide or sulfonamide substituted hydrazine derivatives as JAK kinase inhibitors | 维眸生物科技（上海）有限公司 | 2020-01-24 | — | — | CN | disclosed |