Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.55 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23119939 | 0.91 | CTSK (0.59) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL28830472 | 0.91 | CTSK (0.59) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL28830439 | 0.91 | CTSK (0.59) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL28830425 | 0.83 | CTSK (0.50) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL31317827 | 0.82 | CA1 (0.59) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL17951138 | 0.82 | CA1 (0.59) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL31317808 | 0.82 | CA1 (0.59) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL359203 | 0.81 | CTSK (0.59) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL24068416 | 0.81 | CTSK (0.59) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL3702152 | 0.80 | BTK (0.61) | CTSKBTKCA1CA2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025011633-A1 | ANTAGONIST OF MAS-RELATED G PROTEIN-COUPLED RECEPTOR X2 AND USE THEREOF | 北京普祺医药科技股份有限公司 | 2025-01-16 | — | — | WO | disclosed |
| US-20220071966-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2022-03-10 | — | — | US | disclosed |
| US-11166942-B2 | Inhibitors of integrated stress response pathway | Praxis Biotech LLC (US) | 2021-11-09 | — | — | US | disclosed |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2020-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11166942-B2 | Inhibitors of integrated stress response pathway | ATF4, DDIT3, ATF1 | CTSK 3839/4885BTK 1436/4885CA1 4637/4885 |
| US-20220071966-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | CTSK 3839/4885BTK 1436/4885CA1 4637/4885 |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | CTSK 3839/4885BTK 1436/4885CA1 4637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.