Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | NPC1 | O15118 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.59 |
| ▸ | PPIA | P62937 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4122858 | 0.84 | NPC1 (0.76) | MAPTNPC1MEN1KMT2APOLB | |
| SCHEMBL828067 | 0.84 | ALOX15 (0.71) | MAPTNPC1MEN1KMT2APOLB | |
| SCHEMBL5657576 | 0.83 | NPC1 (0.78) | MAPTNPC1MEN1KMT2APOLB | |
| SCHEMBL31054249 | 0.82 | NPC1 (1.00) | MAPTNPC1MEN1KMT2APOLB | |
| SCHEMBL651929 | 0.82 | NPC1 (1.00) | MAPTNPC1MEN1KMT2APOLB | |
| SCHEMBL28830841 | 0.81 | NPC1 (0.74) | MAPTNPC1MEN1KMT2APOLB | |
| SCHEMBL5658310 | 0.80 | NPC1 (0.88) | MAPTNPC1MEN1KMT2APOLB | |
| SCHEMBL5816874 | 0.79 | NPC1 (0.61) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL31054258 | 0.79 | NPC1 (0.77) | MAPTNPC1MEN1KMT2APOLB | |
| SCHEMBL19631311 | 0.78 | NPC1 (0.80) | MAPTNPC1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114957117-A | N-substituted-4- [3- (quinoline-6-yl) ureido ] benzoyl hydrazine derivative and preparation method and application thereof | 浙江师范大学行知学院 | 2022-08-30 | — | — | CN | disclosed |