Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.55 |
| ▸ | BRD4 | O60885 | 6/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | OXTR | P30559 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224148 | 0.72 | KCNH2 (1.00) | KCNH2FYN | |
| SCHEMBL16651342 | 0.71 | BRD4 (0.68) | BRD4 | |
| SCHEMBL28924973 | 0.71 | PIK3CA (0.56) | BRD4 | |
| SCHEMBL2226479 | 0.69 | KCNH2 (0.90) | KCNH2PTGS1PTGS2FYN | |
| SCHEMBL562021 | 0.69 | PIK3CD (0.58) | KCNH2PTGS1PTGS2 | |
| SCHEMBL2227426 | 0.68 | KCNH2 (0.78) | KCNH2FYNOXTR | |
| SCHEMBL6050909 | 0.67 | PTGS2 (0.65) | KCNH2PTGS1PTGS2FYNOXTR | |
| SCHEMBL6050719 | 0.67 | KCNH2 (0.63) | KCNH2PTGS1PTGS2FYNOXTR | |
| SCHEMBL30519619 | 0.67 | CYP2A6 (0.50) | — | |
| SCHEMBL1423797 | 0.67 | CYP2A6 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059788-A1 | PYRAZOLOPYRIDINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-05-27 | — | — | WO | claimed |