Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.39 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31017480 | 0.81 | POLB (0.41) | POLBKMT2AHSD11B1LMNA | |
| SCHEMBL16791886 | 0.79 | HTT (0.44) | POLBKMT2AHSD11B1LMNA | |
| SCHEMBL28059194 | 0.78 | ALDH1A1 (0.47) | KMT2ACYP1A2LMNATDP1 | |
| SCHEMBL31017504 | 0.78 | TDP1 (0.46) | POLBEPHX2KMT2ACYP1A2LMNA | |
| SCHEMBL15931753 | 0.76 | HTT (0.53) | CA12CA1CA9KMT2ALMNA | |
| SCHEMBL3223897 | 0.76 | POLB (0.37) | POLBKMT2ALMNATDP1 | |
| SCHEMBL5257 | 0.74 | POLB (0.68) | POLBEPHX2CA2CA12CA1 | |
| SCHEMBL30843794 | 0.73 | CA2 (0.43) | POLBEPHX2CA2CA12CA1 | |
| SCHEMBL3704606 | 0.72 | CA2 (0.46) | POLBEPHX2CA2CA12CA1 | |
| Hydrochloric Acid SCHEMBL659692 | 0.72 | POLB (0.65) | POLBEPHX2CA2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814045-B | Imidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2017-08-25 | — | — | CN | disclosed |
| CN-105814045-A | Imidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |