Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019745 | 0.90 | PHF8 (0.39) | PHF8KDM2AFAAHMEN1KMT2A | |
| SCHEMBL6222620 | 0.86 | ALDH1A1 (0.48) | PHF8KDM2AMEN1KMT2ALMNA | |
| SCHEMBL25615304 | 0.82 | PHF8 (0.31) | PHF8KDM2AMEN1KMT2AALDH1A1 | |
| SCHEMBL15684245 | 0.81 | PHF8 (0.54) | PHF8KDM2ALMNATSHRALDH1A1 | |
| SCHEMBL5117460 | 0.81 | ALDH1A1 (0.37) | MEN1KMT2ALMNATSHRALDH1A1 | |
| SCHEMBL24703880 | 0.80 | ALDH1A1 (0.42) | PHF8KDM2AMEN1KMT2ALMNA | |
| SCHEMBL22205611 | 0.80 | LMNA (0.44) | PHF8KDM2AMEN1KMT2ALMNA | |
| SCHEMBL16050328 | 0.79 | TSHR (0.59) | PHF8KDM2AMEN1KMT2ALMNA | |
| SCHEMBL24096185 | 0.79 | PHF8 (0.32) | PHF8KDM2AMEN1KMT2A | |
| SCHEMBL99297 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118344372-A | Substituted straight-chain spiro derivatives | 詹森药业有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-118255774-A | Substituted straight-chain spiro derivatives | 詹森药业有限公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-118255773-A | Substituted straight-chain spiro derivatives | 詹森药业有限公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-114867721-A | Substituted straight-chain spiro derivatives | 詹森药业有限公司 | 2022-08-05 | — | — | CN | disclosed |