Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6906435 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2SLC22A12RPS6KA3KDM4EALDH1A1 | |
| SCHEMBL30292662 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2SLC22A12RPS6KA3KDM4EALDH1A1 | |
| SCHEMBL30292657 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2SLC22A12RPS6KA3KDM4EALDH1A1 | |
| SCHEMBL2222831 | 0.80 | ALDH1A1 (0.50) | SLC22A12RPS6KA3KDM4EALDH1A1DHODH | |
| SCHEMBL2558137 | 0.79 | MAPT (0.46) | SMN1; SMN2SLC22A12RPS6KA3KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7279409 | 0.78 | ALDH1A1 (0.49) | SLC22A12RPS6KA3KDM4EALDH1A1CYP1A2 | |
| SCHEMBL4245149 | 0.77 | KDM4E (0.64) | SMN1; SMN2CHEK1KDM4EALDH1A1LMNA | |
| SCHEMBL31325750 | 0.77 | MKNK1 (0.42) | SMN1; SMN2SLC22A12KDM4EALDH1A1CYP2D6 | |
| SCHEMBL30863845 | 0.77 | KDM4C (0.57) | KDM4EALDH1A1GAAMAPT | |
| SCHEMBL31720261 | 0.77 | CYP11B1 (0.52) | SMN1; SMN2CHEK1ALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645756-B2 | 6-[4-(3-piperidin-1-ylpropoxy)-phenyl]-[1,2,4]triazolo[4,3-b]pyridazine; has histamine-H3 receptor antagonistic effect or a histamine-H3 receptor inverse-agonistic effect; for metabolic system, circulatory system or nervous system diseases | BANYU PHARMACEUTICAL CO. LTD. (JP) | 2010-01-12 | — | — | US | disclosed |
| US-20070167453-A1 | Nitrogenous fused heteroaromatic ring derivative | MSD K.K. (JP) | 2007-07-19 | — | — | US | disclosed |
| EP-1719756-A1 | NITROGENOUS FUSED HETEROAROMATIC RING DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-11-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167453-A1 | Nitrogenous fused heteroaromatic ring derivative | HRH3, HRH2, HRH4 | SMN1; SMN2 2656/4885SLC22A12 1372/4885CHEK1 3563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.