Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13724486 | 0.96 | SYK (0.44) | ROCK2ROCK1SYKPDE4BMEN1 | |
| SCHEMBL1073886 | 0.71 | SYK (0.64) | SYK | |
| SCHEMBL14320787 | 0.70 | CDK8 (0.47) | KMT2AKDM4EALDH1A1HTT | |
| SCHEMBL15598761 | 0.70 | POLB (0.49) | MEN1KMT2AHRH4KDM4EALDH1A1 | |
| SCHEMBL7708469 | 0.67 | ROCK2 (0.49) | ROCK2ROCK1MEN1KMT2AHRH4 | |
| SCHEMBL12809767 | 0.66 | SYK (0.43) | ROCK2ROCK1SYKPDE4BMEN1 | |
| SCHEMBL7708586 | 0.66 | KDM4E (0.46) | ROCK2ROCK1MEN1KMT2AHRH4 | |
| SCHEMBL7712423 | 0.65 | HTR2A (0.44) | ROCK2ROCK1PDE4BMEN1KMT2A | |
| SCHEMBL3248485 | 0.65 | KDM4E (0.46) | ROCK2ROCK1MEN1KMT2AHRH4 | |
| SCHEMBL13724515 | 0.65 | MAP4K1 (0.39) | ROCK2SYKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |