Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717698 | 0.87 | ALDH1A1 (0.39) | CYP2C19MEN1CYP3A4CYP2C9KMT2A | |
| SCHEMBL13293997 | 0.76 | LMNA (0.51) | LMNA | |
| SCHEMBL1407044 | 0.75 | POLB (0.50) | — | |
| SCHEMBL3436710 | 0.74 | HSP90AA1 (0.39) | CYP2C19MEN1CYP3A4CYP2C9KMT2A | |
| SCHEMBL2521881 | 0.74 | CYP2C19 (0.51) | CYP2C19MEN1KMT2AGAALMNA | |
| SCHEMBL14412764 | 0.71 | HTT (0.36) | MEN1KMT2ALMNASRCPDE4B | |
| SCHEMBL27737544 | 0.70 | NSD2 (0.42) | HTR1AKMT2A | |
| SCHEMBL30753988 | 0.69 | HRH3 (0.70) | HRH3HTR1AHTR2CGAASRC | |
| SCHEMBL13724486 | 0.69 | SYK (0.44) | SYKCYP2C19MEN1CYP3A4CYP2C9 | |
| SCHEMBL12434763 | 0.68 | L3MBTL1 (0.43) | GAALMNATP53MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295411-A1 | Pyrazoles as 11-beta-hsd-1 | F. Hoffmann-La Roche AG (CH) | 2011-03-16 | — | — | EP | disclosed |