Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29887105 | 1.00 | MAPT (0.49) | MAPTSMN1; SMN2ALOX15HSD17B10ALOX12 | |
| SCHEMBL29887039 | 0.84 | MAPT (0.48) | MAPTSMN1; SMN2ALOX15HSD17B10ALOX12 | |
| SCHEMBL28833540 | 0.84 | MAPT (0.48) | MAPTSMN1; SMN2ALOX15HSD17B10ALOX12 | |
| SCHEMBL30353482 | 0.80 | GAA (0.55) | MAPTSMN1; SMN2HTR6GAAMEN1 | |
| SCHEMBL23673431 | 0.75 | TSHR (0.59) | SMN1; SMN2KDM4EPOLBALDH1A1 | |
| SCHEMBL13243994 | 0.75 | SIRT6 (0.63) | MAPTHTR6GAAMEN1GLA | |
| SCHEMBL23673444 | 0.75 | HTR6 (0.38) | MAPTSMN1; SMN2HSD17B10HTR6GAA | |
| SCHEMBL9937031 | 0.74 | SMN1; SMN2 (0.49) | MAPTSMN1; SMN2ALOX15HSD17B10ALOX12 | |
| SCHEMBL2384047 | 0.74 | SIRT6 (0.58) | MAPTSMN1; SMN2HTR6GAAMEN1 | |
| SCHEMBL30602337 | 0.74 | AGXT (0.44) | MAPTSMN1; SMN2HTR6GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114981251-B | Dibenzofuran derivative cathepsin K inhibitor and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-114981251-A | Diphenyl furan derivative cathepsin K inhibitor and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2022-08-30 | — | — | CN | disclosed |