SCHEMBL28833686

SCHEMBL28833686

NC(=O)c1csnn1.NC(=O)c1nccs1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
TSHR P16473 3/20 0.39
ATM Q13315 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
ADORA3 P0DMS8 1/20 0.36
MC4R P32245 1/20 0.36
ADRA1A P35348 1/20 0.36
MC3R P41968 1/20 0.36
CYP2D6 P10635 3/20 0.35
CYP2C19 P33261 2/20 0.35
CYP3A4 P08684 1/20 0.35
MAPT P10636 4/20 0.35
LMNA P02545 1/20 0.34
RBBP9 O75884 3/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
HPGD P15428 1/20 0.33
HSD17B10 Q99714 1/20 0.33
THRB P10828 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL157088 0.81
SCHEMBL158422 0.81
SCHEMBL31461088 0.79
Hydrochloric Acid SCHEMBL27718659 0.79
Potassium SCHEMBL31461086 0.79
Ammonia Solution, Strong SCHEMBL28224778 0.79
Hydrochloric Acid SCHEMBL5013504 0.79 ALDH1A1 (0.59) ALDH1A1TSHRL3MBTL1CYP2D6CYP2C19
SCHEMBL31461084 0.79
SCHEMBL28853121 0.77 TSHR (0.45) ALDH1A1TSHRATML3MBTL1ADORA3
Ammonia Solution, Strong SCHEMBL28224779 0.77 ALDH1A1 (0.57) ALDH1A1TSHRL3MBTL1CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105873925-B Antiparasitic and insecticidal isoxazoline compounds 勃林格殷格翰动物保健美国公司 2019-09-10 CN disclosed
CN-105873925-A Antiparasitic and insecticidal isoxazoline compounds 梅里亚股份有限公司 2016-08-17 CN disclosed