Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718039 | 1.00 | ALOX15 (0.43) | ALOX15GRIK2HDAC4SMN1; SMN2NPSR1 | |
| SCHEMBL1718035 | 1.00 | ALOX15 (0.43) | ALOX15GRIK2HDAC4SMN1; SMN2NPSR1 | |
| SCHEMBL1718034 | 1.00 | ALOX15 (0.43) | ALOX15GRIK2HDAC4SMN1; SMN2NPSR1 | |
| SCHEMBL28833830 | 1.00 | ALOX15 (0.43) | ALOX15GRIK2HDAC4SMN1; SMN2NPSR1 | |
| SCHEMBL6635115 | 1.00 | ALOX15 (0.43) | ALOX15GRIK2HDAC4SMN1; SMN2NPSR1 | |
| SCHEMBL16821111 | 0.87 | GBA1 (0.44) | ALOX15GRIK2HDAC4SMN1; SMN2NPSR1 | |
| SCHEMBL14762269 | 0.87 | GBA1 (0.44) | ALOX15GRIK2HDAC4SMN1; SMN2NPSR1 | |
| SCHEMBL199463 | 0.81 | SLC1A2 (0.47) | HDAC4AKR1C3AKR1C1 | |
| SCHEMBL199461 | 0.81 | SLC1A2 (0.47) | HDAC4AKR1C3AKR1C1 | |
| SCHEMBL350996 | 0.81 | SLC1A2 (0.47) | HDAC4AKR1C3AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114980976-A | Covalent RAS inhibitors and uses thereof | 锐新医药公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-114901366-A | RAS inhibitors | 锐新医药公司 | 2022-08-12 | — | — | CN | disclosed |