SCHEMBL28834050

SCHEMBL28834050

N#Cc1cccc2c(OC3CCNCC3)ccnc12

nearest known ligand 0.57

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
AR P10275 12/20 0.57
TBK1 Q9UHD2 5/20 0.40
IKBKE Q14164 4/20 0.40
TLR9 Q9NR96 1/20 0.40
TLR7 Q9NYK1 1/20 0.40
MAP3K5 Q99683 1/20 0.39
ROCK2 O75116 1/20 0.39
ROCK1 Q13464 1/20 0.39
CDC42BPB Q9Y5S2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL23360590 0.99 AR (0.56) ARTBK1IKBKETLR9TLR7
Hydrochloric Acid SCHEMBL29862491 0.99 AR (0.56) ARTBK1IKBKETLR9TLR7
Hydrochloric Acid SCHEMBL23360004 0.80 HTR1A (0.44) ARROCK2ROCK1CDC42BPB
Hydrochloric Acid SCHEMBL23359626 0.80 AR (0.53) AR
Hydrochloric Acid SCHEMBL23360080 0.79 HTR1A (0.46) ARROCK2ROCK1CDC42BPB
SCHEMBL12835899 0.78 AR (0.45) AR
SCHEMBL4120430 0.75 HRH1 (0.57) MAP3K5
SCHEMBL23142962 0.75 AR (0.49) ARTBK1IKBKE
SCHEMBL31330724 0.75 AR (0.49) ARTBK1IKBKE
SCHEMBL23142905 0.75 AR (0.49) ARTBK1IKBKE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114867719-A Pyrrolidine and piperidine compounds 柳韩洋行 2022-08-05 CN disclosed