Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 4/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | PPARD | Q03181 | 3/20 | 0.34 |
| ▸ | PPARA | Q07869 | 3/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28071113 | 0.88 | DRD2 (0.49) | DRD2DRD4MAOBMAOAACHE | |
| SCHEMBL16558085 | 0.79 | MAPT (0.47) | DRD2DRD4MAOBMAOAPPARG | |
| Indoline SCHEMBL28255834 | 0.79 | MAOA (0.43) | DRD2DRD4MAOBMAOAPARP11 | |
| SCHEMBL18055468 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2GFERDRD2DRD4MAOB | |
| SCHEMBL13548843 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2GFERDRD2DRD4MAOB | |
| SCHEMBL28124763 | 0.74 | EIF2AK2 (0.51) | MAOBMAOAS1PR1 | |
| SCHEMBL27645613 | 0.73 | RXRB (0.50) | SMN1; SMN2GFERALDH1A1MAPTHRH3 | |
| SCHEMBL5541345 | 0.73 | SMN1; SMN2 (0.41) | SMN1; SMN2GFERDRD2DRD4PPARG | |
| SCHEMBL8892613 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2GFERDRD2DRD4PPARG | |
| SCHEMBL13369061 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2GFERDRD2DRD4PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106565682-B | Substituted indole expires ketone derivatives and application thereof | 沈阳药科大学 | 2019-07-16 | — | — | CN | claimed |
| CN-109302846-A | Indolinone compounds and their use in the treatment of fibrotic diseases | 莱斯彼维特有限公司 | 2019-02-01 | — | — | CN | claimed |
| CN-109153666-A | Indole derivatives and its purposes as kinases inhibitor | 莱斯彼维特有限公司 | 2019-01-04 | — | — | CN | claimed |
| CN-109153666-A | Indole derivatives and its purposes as kinases inhibitor | 莱斯彼维特有限公司 | 2019-01-04 | — | — | CN | disclosed |
| CN-106456602-A | Substituted indole MCL-1 inhibitors | 范德比尔特大学 | 2017-02-22 | — | — | CN | disclosed |