SCHEMBL28837145

SCHEMBL28837145

CC(C)(C)c1ccc(-c2c(CC(F)(F)F)oc3ccccc23)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 10/20 0.44
MAPT P10636 2/20 0.43
CYP1A1 P04798 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2E1 P05181 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C8 P10632 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2A6 P11509 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP4B1 P13584 1/20 0.38
CYP2B6 P20813 1/20 0.38
CYP3A5 P20815 1/20 0.38
CYP2A7 P20853 1/20 0.38
CYP3A7 P24462 1/20 0.38
CYP2F1 P24903 1/20 0.38
CYP2C18 P33260 1/20 0.38
CYP2C19 P33261 1/20 0.38
CYP2J2 P51589 1/20 0.38
CYP4F2 P78329 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29926778 1.00 PTPN1 (0.44) PTPN1MAPTCYP1A1CYP1A2CYP2E1
SCHEMBL28837163 0.86 PTPN1 (0.46) PTPN1MAPTPTGS2
SCHEMBL29926945 0.86 PTPN1 (0.46) PTPN1MAPTPTGS2
SCHEMBL29927513 0.85 MAPT (0.52) PTPN1MAPTCYP3A4CYP1B1PTPRF
SCHEMBL28837150 0.85 MAPT (0.52) PTPN1MAPTCYP3A4CYP1B1PTPRF
SCHEMBL29926908 0.84 PTGS2 (0.46) PTPN1MAPTPTGS2PTPRFPTPRA
SCHEMBL28837148 0.84 PTGS2 (0.46) PTPN1MAPTPTGS2PTPRFPTPRA
SCHEMBL28837144 0.84 L3MBTL1 (0.43) PTPN1MAPTCYP1A1CYP1A2CYP1B1
SCHEMBL29927072 0.82 MAOB (0.50) PTPN1MAPTCYP3A4CYP2C9MEN1
SCHEMBL28837166 0.82 MAOB (0.50) PTPN1MAPTCYP3A4CYP2C9MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115043802-A Synthesis method of trifluoroethyl benzofuran compound 温州大学 2022-09-13 CN disclosed