Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethane SCHEMBL28093262 | 0.88 | LMNA (0.47) | TDP1LMNAALDH1A1USP2TSHR | |
| SCHEMBL30755 | 0.88 | LMNA (0.53) | TDP1LMNAALDH1A1USP2TSHR | |
| Propane SCHEMBL27657560 | 0.86 | USP2 (0.46) | TDP1LMNAALDH1A1USP2TSHR | |
| SCHEMBL29061893 | 0.85 | LMNA (0.50) | TDP1LMNAALDH1A1USP2TSHR | |
| Water SCHEMBL22418486 | 0.85 | LMNA (0.50) | TDP1LMNAALDH1A1USP2TSHR | |
| Glycerin SCHEMBL28165911 | 0.85 | LMNA (0.60) | TDP1LMNAALDH1A1USP2TSHR | |
| SCHEMBL27261364 | 0.85 | LMNA (0.50) | TDP1LMNAALDH1A1USP2TSHR | |
| Water SCHEMBL28545207 | 0.85 | LMNA (0.50) | TDP1LMNAALDH1A1USP2TSHR | |
| Water SCHEMBL27953222 | 0.85 | LMNA (0.50) | TDP1LMNAALDH1A1USP2TSHR | |
| Propylene Glycol SCHEMBL2236346 | 0.83 | TDP1 (0.56) | TDP1LMNAALDH1A1USP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106232114-A | The prevention of peripheral neuropathy or improvement compositions | 味之素株式会社 | 2016-12-14 | — | — | CN | disclosed |