Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.63 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | BCL6 | P41182 | 1/20 | 0.52 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.47 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138709 | 0.84 | KIF11 (0.80) | KIF11BCL6PTK2BCRBNGAA | |
| SCHEMBL22425175 | 0.82 | GRIN1 (0.56) | KIF11MAOBGRIN1GRIN2BHDAC3 | |
| SCHEMBL152963 | 0.81 | AHR (0.61) | KIF11MAOBAHRGAAHDAC3 | |
| SCHEMBL1897593 | 0.80 | PDE3B (0.68) | KIF11MAOBAHRGAAGRIA1 | |
| SCHEMBL395562 | 0.78 | KIF11 (0.66) | KIF11BCL6PTK2BAHRCRBN | |
| SCHEMBL688480 | 0.77 | PKM (0.79) | PKMGAA | |
| SCHEMBL16208518 | 0.77 | KIF11 (1.00) | KIF11PTK2BPKMGAA | |
| SCHEMBL12361998 | 0.77 | AHR (0.56) | KIF11BCL6PTK2BAHRPKM | |
| SCHEMBL4222634 | 0.76 | PDE3B (0.45) | KIF11MAOBTNIKGRIN1GRIN2B | |
| SCHEMBL3226228 | 0.76 | S1PR1 (0.54) | KIF11MAOBBCL6PTK2BTNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106316923-A | Disubstituted indol-2(1H)-one derivative and preparation method and application thereof | 中南大学 | 2017-01-11 | — | — | CN | disclosed |