Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23342685 | 1.00 | MEN1 (0.51) | MEN1KMT2AMAPTL3MBTL1GPR119 | |
| SCHEMBL23298099 | 0.86 | MEN1 (0.41) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL23298100 | 0.86 | MEN1 (0.41) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL30419761 | 0.85 | PDK1 (0.42) | MEN1KMT2AMAPTL3MBTL1GPR119 | |
| SCHEMBL21699513 | 0.85 | MEN1 (0.47) | MEN1KMT2AMAPTL3MBTL1GPR119 | |
| SCHEMBL17567266 | 0.85 | MEN1 (0.47) | MEN1KMT2AMAPTL3MBTL1GPR119 | |
| SCHEMBL29543052 | 0.83 | TSHR (0.46) | MEN1KMT2AL3MBTL1ALDH1A1POLB | |
| SCHEMBL31703718 | 0.82 | KMT2A (0.57) | MEN1KMT2AMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL31228320 | 0.82 | TACR1 (0.43) | MEN1KMT2AMAPTL3MBTL1GPR119 | |
| SCHEMBL25203184 | 0.81 | POLB (0.45) | MAPTL3MBTL1ALDH1A1POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116209438-A | Treatment of malignant diseases with SHP2 mutations using SOS1 inhibitors | 锐新医药公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-115916194-A | Methods for delaying, preventing and treating acquired resistance to RAS inhibitors | 锐新医药公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115873020-A | RAS inhibitors | 锐新医药公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-114901366-A | RAS inhibitors | 锐新医药公司 | 2022-08-12 | — | — | CN | disclosed |