Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | YAP1 | P46937 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31228526 | 0.90 | TACR1 (0.42) | TACR1JAK2JAK1MEN1KMT2A | |
| SCHEMBL31228440 | 0.86 | AGTR2 (0.40) | TACR1JAK2JAK1MEN1KMT2A | |
| SCHEMBL31228420 | 0.84 | TACR1 (0.42) | TACR1JAK2JAK1MEN1KMT2A | |
| SCHEMBL31153839 | 0.84 | JAK2 (0.46) | JAK2JAK1MEN1KMT2AMAPT | |
| SCHEMBL31153754 | 0.84 | JAK2 (0.46) | JAK2JAK1MEN1KMT2AMAPT | |
| SCHEMBL30419761 | 0.83 | PDK1 (0.42) | TACR1JAK2JAK1MEN1KMT2A | |
| SCHEMBL31228513 | 0.82 | P2RX7 (0.44) | TACR1MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL23342685 | 0.82 | MEN1 (0.51) | JAK2JAK1MEN1KMT2AMAPT | |
| SCHEMBL28838579 | 0.82 | MEN1 (0.51) | JAK2JAK1MEN1KMT2AMAPT | |
| SCHEMBL31228540 | 0.81 | MEN1 (0.39) | MEN1KMT2AMAPTL3MBTL1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |