Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 6/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5371801 | 1.00 | ALDH1A1 (0.43) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL5166307 | 1.00 | ALDH1A1 (0.43) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL5371795 | 1.00 | ALDH1A1 (0.43) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL874439 | 1.00 | ALDH1A1 (0.43) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL874440 | 1.00 | ALDH1A1 (0.43) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL23298241 | 1.00 | ALDH1A1 (0.43) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL874438 | 1.00 | ALDH1A1 (0.43) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL6951727 | 0.85 | NPC1 (0.43) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL3117948 | 0.85 | ALDH1A1 (0.43) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL6950966 | 0.85 | NPC1 (0.43) | ALDH1A1GAAHTTNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116209438-A | Treatment of malignant diseases with SHP2 mutations using SOS1 inhibitors | 锐新医药公司 | 2023-06-02 | — | — | CN | disclosed |
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |
| CN-115916194-A | Methods for delaying, preventing and treating acquired resistance to RAS inhibitors | 锐新医药公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115873020-A | RAS inhibitors | 锐新医药公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-114901366-A | RAS inhibitors | 锐新医药公司 | 2022-08-12 | — | — | CN | disclosed |