SCHEMBL28839002

SCHEMBL28839002

NS(=O)(=O)c1ccc(CN=C=S)c(Cl)c1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MIF P14174 1/20 0.58
CA2 P00918 14/20 0.47
CA1 P00915 12/20 0.47
CA9 Q16790 8/20 0.47
CA12 O43570 4/20 0.47
CA7 P43166 3/20 0.47
CA4 P22748 2/20 0.47
CA6 P23280 2/20 0.47
CA5A P35218 2/20 0.47
CA14 Q9ULX7 2/20 0.47
CA5B Q9Y2D0 2/20 0.47
SLC6A2 P23975 2/20 0.40
SLC6A4 P31645 2/20 0.40
SLC6A3 Q01959 2/20 0.40
PTGS1 P23219 1/20 0.40
PTGS2 P35354 1/20 0.40
VCAM1 P19320 1/20 0.40
CA3 P07451 1/20 0.38
CA13 Q8N1Q1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28839075 0.85 MIF (0.48) MIFCA2CA1CA9CA12
SCHEMBL29836770 0.85 MIF (0.48) MIFCA2CA1CA9CA12
SCHEMBL28839005 0.82 MIF (0.58) MIFCA2CA1CA9CA12
SCHEMBL12409432 0.75 CA2 (0.58) CA2CA1CA9CA12CA7
SCHEMBL1802515 0.75 CA2 (0.58) CA2CA1CA9CA12CA7
SCHEMBL23599328 0.75 CA2 (0.58) CA2CA1CA9CA12CA7
SCHEMBL3365419 0.75 IDO1 (0.48) MIF
SCHEMBL3408447 0.74 MIF (1.00) MIFCA2CA1CA9CA12
SCHEMBL603531 0.74 CA2 (0.56) CA2CA1CA9CA12CA7
SCHEMBL31451546 0.74 CA2 (0.56) CA2CA1CA9CA12CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114890928-A Isothiocyanate derivative and preparation method and application thereof 厦门倍博特医学科技有限公司 2022-08-12 CN disclosed