SCHEMBL28839005

SCHEMBL28839005

NS(=O)(=O)c1ccc(CN=C=S)c(F)c1

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MIF P14174 1/20 0.58
CA2 P00918 18/20 0.52
CA1 P00915 11/20 0.47
CA9 Q16790 5/20 0.47
CA12 O43570 2/20 0.47
CA4 P22748 1/20 0.47
CA6 P23280 1/20 0.47
CA5A P35218 1/20 0.47
CA7 P43166 1/20 0.47
CA14 Q9ULX7 1/20 0.47
CA5B Q9Y2D0 1/20 0.47
EPHX2 P34913 1/20 0.41
NR1H4 Q96RI1 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28839049 0.85 CA2 (0.57) MIFCA2CA1CA9CA12
SCHEMBL29836806 0.85 CA2 (0.57) MIFCA2CA1CA9CA12
SCHEMBL28839002 0.82 MIF (0.58) MIFCA2CA1CA9CA12
SCHEMBL14270191 0.76 CA2 (0.52) CA2CA1CA9CA12CA4
SCHEMBL4585303 0.75 CA2 (0.63) CA2CA1CA9CA12CA4
SCHEMBL19938066 0.75 CA2 (0.63) CA2CA1CA9CA12CA4
SCHEMBL24517597 0.74 CA2 (0.61) CA2CA1CA9CA12CA4
SCHEMBL3408447 0.74 MIF (1.00) MIFCA2CA1CA9CA12
SCHEMBL31451688 0.74 CA2 (0.61) CA2CA1CA9CA12CA4
SCHEMBL4585294 0.74 CA2 (0.61) CA2CA1CA9CA12CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114890928-A Isothiocyanate derivative and preparation method and application thereof 厦门倍博特医学科技有限公司 2022-08-12 CN disclosed