Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Dehydrocorydaline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.61 |
| ▸ | KDM1A | O60341 | 2/20 | 0.98 |
| ▸ | P2RX7 | Q99572 | 12/20 | 0.69 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.65 |
| ▸ | COL1A1 | P02452 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | RAD52 | P43351 | 2/20 | 0.63 |
| ▸ | EP300 | Q09472 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dehydrocorydaline SCHEMBL29695423 | 1.00 | KDM1A (0.98) | KDM1AP2RX7DNMT1COL1A1KDM4E | |
| Dehydrocorydaline SCHEMBL14513602 | 0.99 | KDM1A (1.00) | KDM1AP2RX7DNMT1COL1A1KDM4E | |
| Dehydrocorydaline SCHEMBL29396913 | 0.99 | KDM1A (1.00) | KDM1AP2RX7DNMT1COL1A1KDM4E | |
| Dehydrocorydaline SCHEMBL29944742 | 0.92 | KDM1A (0.87) | KDM1AP2RX7DNMT1COL1A1KDM4E | |
| SCHEMBL16804534 | 0.90 | KDM1A (0.83) | KDM1AP2RX7DNMT1COL1A1KDM4E | |
| SCHEMBL29458821 | 0.90 | KDM1A (0.83) | KDM1AP2RX7DNMT1COL1A1KDM4E | |
| SCHEMBL16804538 | 0.90 | KDM1A (0.83) | KDM1AP2RX7DNMT1COL1A1KDM4E | |
| SCHEMBL13071078 | 0.88 | KDM1A (0.81) | KDM1AP2RX7DNMT1COL1A1KDM4E | |
| SCHEMBL16804540 | 0.86 | KDM1A (0.77) | KDM1AP2RX7DNMT1COL1A1KDM4E | |
| SCHEMBL299398 | 0.85 | P2RX7 (0.78) | KDM1AP2RX7COL1A1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118787637-A | Application of dehydrocorydaline and medicine | 赣江中药创新中心 | 2024-10-18 | — | — | CN | disclosed |
| CN-106614653-A | Sterilizing agent for preventing banana vascular wilt | 徐州顺平生物科技有限公司 | 2017-05-10 | — | — | CN | disclosed |