SCHEMBL28840749

SCHEMBL28840749

COC(=O)Cc1ccc2c(c1)OCC1(CCCCC1)C2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.39
GAA P10253 1/20 0.39
GFER P55789 1/20 0.39
PDK2 Q15119 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C19 P33261 1/20 0.37
CYP4F2 P78329 1/20 0.37
CYP4A11 Q02928 1/20 0.37
HSP90AB1 P08238 1/20 0.35
MAPT P10636 2/20 0.35
TSHR P16473 2/20 0.35
HPGD P15428 2/20 0.35
SMN1; SMN2 Q16637 4/20 0.34
CYP19A1 P11511 1/20 0.34
KMT2A Q03164 1/20 0.33
SLC7A5 Q01650 1/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
EPHX2 P34913 1/20 0.33
LIPE Q05469 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28841012 0.96 ALDH1A1 (0.40) ALDH1A1GAAGFERPDK2CYP3A4
SCHEMBL28841071 0.94 ALDH1A1 (0.42) ALDH1A1GAAGFERPDK2CYP4F2
SCHEMBL28841078 0.85 AKR1B1 (0.41) ALDH1A1GAACYP3A4CYP2C19MAPT
SCHEMBL28953082 0.84 AKR1B1 (0.42) ALDH1A1GAACYP3A4CYP2C19MAPT
SCHEMBL28840757 0.81 AKR1B1 (0.42) ALDH1A1GAACYP3A4CYP2C19MAPT
SCHEMBL28841014 0.78 AKR1B1 (0.44) ALDH1A1GAACYP3A4CYP2C19MAPT
SCHEMBL26087589 0.74 CHRM2 (0.48) ALDH1A1GAAGFERPDK2CYP3A4
SCHEMBL30148842 0.74 AKR1B1 (0.40) ALDH1A1GAACYP3A4CYP2C19MAPT
SCHEMBL30148841 0.71 AKR1B1 (0.40) ALDH1A1GAACYP3A4CYP2C19MAPT
SCHEMBL14414716 0.70 ALDH1A1 (0.43) ALDH1A1GAAGFERPDK2CYP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114907389-A Boronic acid derivatives 首药控股(北京)股份有限公司 2022-08-16 CN disclosed