SCHEMBL28840757

SCHEMBL28840757

O=C(O)Cc1ccc2c(c1)OCC1(CCC1)C2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 2/20 0.42
MCL1 Q07820 1/20 0.38
ALDH1A1 P00352 2/20 0.38
KDM4E B2RXH2 2/20 0.38
MAPT P10636 2/20 0.38
HPGD P15428 2/20 0.38
HSD17B10 Q99714 2/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C19 P33261 1/20 0.38
LTB4R Q15722 1/20 0.38
LTB4R2 Q9NPC1 1/20 0.38
LMNA P02545 2/20 0.37
RGS12 O14924 1/20 0.37
POLB P06746 1/20 0.37
GAA P10253 1/20 0.37
TSHR P16473 1/20 0.37
NFKB1 P19838 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28953082 0.97 AKR1B1 (0.42) AKR1B1MCL1ALDH1A1KDM4EMAPT
SCHEMBL28841078 0.96 AKR1B1 (0.41) AKR1B1MCL1ALDH1A1KDM4EMAPT
SCHEMBL28841014 0.94 AKR1B1 (0.44) AKR1B1MCL1ALDH1A1KDM4EMAPT
SCHEMBL30148841 0.89 AKR1B1 (0.40) AKR1B1MCL1ALDH1A1KDM4EMAPT
SCHEMBL30148842 0.86 AKR1B1 (0.40) AKR1B1MCL1ALDH1A1KDM4EMAPT
SCHEMBL28841012 0.85 ALDH1A1 (0.40) ALDH1A1MAPTHPGDKMT2ACYP3A4
SCHEMBL28840749 0.81 ALDH1A1 (0.39) ALDH1A1MAPTHPGDKMT2ACYP3A4
SCHEMBL28841071 0.79 ALDH1A1 (0.42) ALDH1A1MAPTHPGDMEN1KMT2A
SCHEMBL28840819 0.73 AKR1B1 (0.47) AKR1B1ALDH1A1KDM4EMAPTHPGD
SCHEMBL1669323 0.72 AKR1B1 (0.49) AKR1B1ALDH1A1KDM4EMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114907389-A Boronic acid derivatives 首药控股(北京)股份有限公司 2022-08-16 CN disclosed