Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.49 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1423483 | 0.87 | RIPK1 (0.50) | CCNCCDK8RIPK1SCD5HSD17B10 | |
| SCHEMBL13300490 | 0.87 | RIPK1 (0.50) | CCNCCDK8RIPK1SCD5HSD17B10 | |
| SCHEMBL29515757 | 0.87 | RIPK1 (0.50) | CCNCCDK8RIPK1SCD5HSD17B10 | |
| SCHEMBL17453078 | 0.83 | RIPK1 (0.47) | CCNCCDK8RIPK1SCD5HSD17B10 | |
| SCHEMBL1778275 | 0.81 | NR1H2 (0.53) | CCNCCDK8RIPK1HSD17B10TSHR | |
| SCHEMBL2169785 | 0.81 | NR1H2 (0.53) | CCNCCDK8RIPK1HSD17B10TSHR | |
| SCHEMBL1778276 | 0.81 | NR1H2 (0.53) | CCNCCDK8RIPK1HSD17B10TSHR | |
| SCHEMBL8957415 | 0.80 | CCNC (0.46) | CCNCCDK8RIPK1SCD5HSD17B10 | |
| SCHEMBL15300880 | 0.79 | RIPK1 (0.47) | CCNCCDK8RIPK1TSHRCYP2D6 | |
| SCHEMBL12650282 | 0.78 | CCNC (0.43) | CCNCCDK8RIPK1SCD5HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106817900-A | Novel naphthyridines and isoquinolin and its purposes as CDK8/19 inhibitor | 默克专利有限公司 | 2017-06-09 | — | — | CN | disclosed |