Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 6/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11436917 | 0.83 | RIPK1 (0.60) | RIPK1SCD5 | |
| Hydrochloric Acid SCHEMBL16610762 | 0.83 | MAOA (0.46) | RIPK1MAPK1CYP19A1SPHK2SPHK1 | |
| Hydrochloric Acid SCHEMBL16610587 | 0.83 | MAOA (0.46) | RIPK1MAPK1CYP19A1SPHK2SPHK1 | |
| SCHEMBL28844538 | 0.80 | CCNC (0.51) | CCNCCDK8RIPK1SCD5CYP2D6 | |
| SCHEMBL13300490 | 0.77 | RIPK1 (0.50) | CCNCCDK8RIPK1SCD5CYP2D6 | |
| SCHEMBL29515757 | 0.77 | RIPK1 (0.50) | CCNCCDK8RIPK1SCD5CYP2D6 | |
| SCHEMBL1423483 | 0.77 | RIPK1 (0.50) | CCNCCDK8RIPK1SCD5CYP2D6 | |
| SCHEMBL30964008 | 0.76 | SPHK2 (0.43) | RIPK1SPHK2SPHK1 | |
| SCHEMBL17453078 | 0.74 | RIPK1 (0.47) | CCNCCDK8RIPK1SCD5CYP2D6 | |
| SCHEMBL4575164 | 0.73 | CCNC (0.44) | CCNCCDK8RIPK1SCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690851-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | Astra Aktiebolag (SE) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021621-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1994-09-29 | — | — | WO | disclosed |