Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KAT7 | O95251 | 2/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | RXRG | P48443 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL176302 | 0.80 | PREP (0.38) | MRGPRX4NAMPTPREPLRRK2RXRA | |
| SCHEMBL28148776 | 0.80 | CA12 (0.49) | LMNAMAPTKAT7KAT6ACA12 | |
| SCHEMBL28150075 | 0.80 | CA12 (0.49) | LMNAMAPTKAT7KAT6ACA12 | |
| SCHEMBL28844823 | 0.79 | CA12 (0.58) | LMNAMAPTKAT7KAT6ACA12 | |
| SCHEMBL22446082 | 0.76 | CA12 (0.52) | LMNAKAT7KAT6ACA12CA1 | |
| SCHEMBL31307742 | 0.73 | MAOB (0.54) | MEN1KMT2ALMNAMAPTHPGD | |
| SCHEMBL27923228 | 0.73 | CA12 (0.65) | MEN1KMT2AMAPTKAT7KAT6A | |
| SCHEMBL28953341 | 0.72 | CA12 (0.50) | LMNAMAPTKAT7KAT6ACA12 | |
| SCHEMBL28149935 | 0.72 | CA12 (0.50) | LMNAMAPTKAT7KAT6ACA12 | |
| SCHEMBL28845079 | 0.72 | CA12 (0.49) | MAPTKAT7KAT6ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103384668-B | compounds and compositions for inhibition of NAMPT | 福马TM有限责任公司 | 2017-05-31 | — | — | CN | claimed |