SCHEMBL28845188

SCHEMBL28845188

CCC(C)(C)c1c(C)ccc2c1C(=O)c1ccccc1C2=O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 10/20 0.54
MAPK1 P28482 7/20 0.54
RAB9A P51151 7/20 0.54
NPC1 O15118 6/20 0.54
LMNA P02545 4/20 0.54
CASP3 P42574 3/20 0.54
SENP7 Q9BQF6 3/20 0.54
SENP6 Q9GZR1 3/20 0.54
SENP8 Q96LD8 2/20 0.54
ATM Q13315 1/20 0.54
ALDH1A1 P00352 7/20 0.53
L3MBTL1 Q9Y468 5/20 0.53
CYP3A4 P08684 3/20 0.53
ELANE P08246 3/20 0.53
TSHR P16473 2/20 0.53
HBB P68871 1/20 0.53
MAPT P10636 8/20 0.41
KDM4E B2RXH2 2/20 0.41
PABPC1 P11940 2/20 0.41
PARG Q86W56 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20735614 0.83 ALDH1A1 (0.59) SMN1; SMN2MAPK1RAB9ANPC1LMNA
SCHEMBL898756 0.76 SMN1; SMN2 (0.47) SMN1; SMN2MAPK1RAB9ANPC1LMNA
SCHEMBL30069214 0.76 MAPK1 (0.54) SMN1; SMN2MAPK1RAB9ANPC1LMNA
SCHEMBL187695 0.76 MAPK1 (0.54) SMN1; SMN2MAPK1RAB9ANPC1LMNA
SCHEMBL769353 0.74 ALDH1A1 (0.75) SMN1; SMN2MAPK1RAB9ANPC1LMNA
SCHEMBL29501107 0.72 ALDH1A1 (0.67) SMN1; SMN2MAPK1RAB9ANPC1LMNA
SCHEMBL57336 0.72 ALDH1A1 (0.67) SMN1; SMN2MAPK1RAB9ANPC1LMNA
Anthraquinone SCHEMBL28722242 0.71 RAB9A (0.71) SMN1; SMN2MAPK1RAB9ANPC1LMNA
SCHEMBL187755 0.70 NPC1 (1.00) SMN1; SMN2MAPK1RAB9ANPC1LMNA
SCHEMBL29482674 0.70 NPC1 (1.00) SMN1; SMN2MAPK1RAB9ANPC1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106660919-B Preparation of 2, 6-and 2, 7-disubstituted anthraquinone derivatives 巴斯夫欧洲公司 2019-10-11 CN disclosed
CN-106660919-A preparation of 2, 6-and 2, 7-disubstituted anthraquinone derivatives 巴斯夫欧洲公司 2017-05-10 CN disclosed