Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 8/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | WDR5 | P61964 | 4/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28845823 | 0.88 | SIRT6 (0.69) | SIRT6ALDH1A1WDR5PLK1MAPT | |
| SCHEMBL28845819 | 0.88 | SIRT6 (0.50) | SIRT6ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL29891093 | 0.81 | WDR5 (0.59) | SIRT6ALDH1A1WDR5MAPTLMNA | |
| SCHEMBL28900077 | 0.81 | SIRT6 (0.81) | SIRT6ALDH1A1PLK1MAPTMAPK1 | |
| SCHEMBL22652232 | 0.81 | SIRT6 (1.00) | SIRT6ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL31739551 | 0.79 | SIRT6 (0.63) | SIRT6ALDH1A1WDR5MAPTLMNA | |
| SCHEMBL28845809 | 0.76 | SIRT6 (0.51) | SIRT6ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL1890774 | 0.73 | SIRT6 (0.61) | SIRT6ALDH1A1WDR5MAPTLMNA | |
| SCHEMBL5054829 | 0.73 | MAPT (0.64) | SIRT6ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL5624466 | 0.73 | SIRT6 (0.76) | SIRT6ALDH1A1MAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109734674-B | Aniline WDR5 protein-protein interaction inhibitor and preparation method and application thereof | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |