Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28156718 | 0.88 | KAT6A (0.50) | SMN1; SMN2RAB9ANPC1LMNAMAPT | |
| SCHEMBL28157274 | 0.83 | KAT6A (0.57) | SMN1; SMN2RAB9ANPC1LMNAMAPT | |
| SCHEMBL28156712 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2RAB9ANPC1LMNATP53 | |
| SCHEMBL28157305 | 0.83 | MEN1 (0.48) | SMN1; SMN2RAB9ANPC1LMNATP53 | |
| SCHEMBL28156748 | 0.83 | LMNA (0.41) | SMN1; SMN2RAB9ANPC1LMNAMAPT | |
| SCHEMBL16338142 | 0.82 | CFTR (0.48) | SMN1; SMN2RAB9ANPC1LMNATP53 | |
| SCHEMBL28846379 | 0.81 | HPGD (0.52) | SMN1; SMN2RAB9ANPC1LMNATP53 | |
| SCHEMBL28156717 | 0.80 | MEN1 (0.50) | SMN1; SMN2RAB9ANPC1LMNATP53 | |
| SCHEMBL28156742 | 0.79 | LMNA (0.52) | SMN1; SMN2RAB9ANPC1LMNATP53 | |
| SCHEMBL28846257 | 0.77 | MEN1 (0.47) | SMN1; SMN2RAB9ANPC1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105531268-B | Noval chemical compound and its pharmaceutical composition for treating cystic fibrosis | 加拉佩格斯股份有限公司 | 2017-09-12 | — | — | CN | disclosed |