Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28157305 | 0.86 | MEN1 (0.48) | MEN1KMT2ATDP1SMN1; SMN2GAA | |
| SCHEMBL28846257 | 0.85 | MEN1 (0.47) | MEN1KMT2ATDP1SMN1; SMN2GAA | |
| SCHEMBL28156725 | 0.84 | NPC1 (0.47) | MEN1KMT2ASMN1; SMN2GAALMNA | |
| SCHEMBL28846379 | 0.84 | HPGD (0.52) | MEN1KMT2ATDP1SMN1; SMN2GAA | |
| SCHEMBL28156718 | 0.84 | KAT6A (0.50) | MEN1KMT2ATDP1SMN1; SMN2GAA | |
| SCHEMBL28157364 | 0.82 | LMNA (0.45) | MEN1KMT2ATDP1SMN1; SMN2GAA | |
| SCHEMBL28156742 | 0.82 | LMNA (0.52) | MEN1KMT2ATDP1SMN1; SMN2LMNA | |
| SCHEMBL28846263 | 0.80 | SMN1; SMN2 (0.42) | MEN1KMT2ATDP1SMN1; SMN2GAA | |
| SCHEMBL28156720 | 0.80 | MAPT (0.64) | MEN1KMT2ASMN1; SMN2GAALMNA | |
| SCHEMBL28157321 | 0.80 | TP53 (0.44) | MEN1KMT2ATDP1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105531268-B | Noval chemical compound and its pharmaceutical composition for treating cystic fibrosis | 加拉佩格斯股份有限公司 | 2017-09-12 | — | — | CN | disclosed |