Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28847154 | 0.72 | MAPK1 (0.53) | MAPTHDAC1HDAC3HDAC2LMNA | |
| SCHEMBL28847140 | 0.67 | MAPT (0.64) | MAPTHDAC1HDAC3HDAC2TP53 | |
| SCHEMBL10884343 | 0.67 | LMNA (0.74) | MAPTALDH1A1L3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL31171396 | 0.67 | HDAC3 (0.68) | MAPTHDAC1HDAC3HDAC2ALDH1A1 | |
| SCHEMBL27726301 | 0.66 | HDAC1 (0.63) | MAPTHDAC1HDAC3HDAC2TP53 | |
| SCHEMBL11194354 | 0.66 | MAPT (0.74) | MAPTTP53ALDH1A1HTTL3MBTL1 | |
| SCHEMBL29155474 | 0.66 | LMNA (0.72) | MAPTALDH1A1L3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL8819152 | 0.66 | KDM4D (0.68) | MAPTHDAC1HDAC3HDAC2TP53 | |
| SCHEMBL1520536 | 0.65 | HDAC1 (0.70) | MAPTHDAC1HDAC3HDAC2TP53 | |
| SCHEMBL7251498 | 0.65 | EPHX2 (0.61) | HDAC1EPHX2ALDH1A1HTTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109836378-B | Sphingomyelin synthase inhibitor, preparation method and application thereof | 上海华汇拓医药科技有限公司 | 2022-09-30 | — | — | CN | claimed |
| CN-109836378-B | Sphingomyelin synthase inhibitor, preparation method and application thereof | 上海华汇拓医药科技有限公司 | 2022-09-30 | — | — | CN | disclosed |