Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11194354 | 0.81 | MAPT (0.74) | MAPTTP53SMN1; SMN2ALDH1A1ALOX15 | |
| SCHEMBL19133763 | 0.80 | HSD17B10 (0.60) | MAPTPOLBTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL30322830 | 0.80 | HSD17B10 (0.60) | MAPTPOLBTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL21118532 | 0.79 | MAPT (0.58) | MAPTTP53TSHRALDH1A1ALOX15 | |
| SCHEMBL28847138 | 0.79 | LMNA (0.49) | MAPTTP53TSHRALDH1A1LMNA | |
| SCHEMBL29989633 | 0.79 | MAPT (1.00) | MAPTPOLBTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL4651272 | 0.79 | MAPT (1.00) | MAPTPOLBTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL31261694 | 0.74 | NAMPT (0.55) | MAPTTSHRSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL29865428 | 0.71 | MAPT (0.66) | MAPTTP53POLBTSHRSMN1; SMN2 | |
| SCHEMBL2330387 | 0.70 | ALDH1A1 (0.73) | MAPTTP53POLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109836378-B | Sphingomyelin synthase inhibitor, preparation method and application thereof | 上海华汇拓医药科技有限公司 | 2022-09-30 | — | — | CN | disclosed |