Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20262310 | 0.89 | MAPK14 (0.37) | MAPK14CNR2BRD9ITGA4ITGB7 | |
| SCHEMBL20262308 | 0.89 | MAPK14 (0.37) | MAPK14CNR2BRD9ITGA4ITGB7 | |
| SCHEMBL6133365 | 0.84 | BRD9 (0.35) | MAPK14CNR2BRD9ITGA4ITGB7 | |
| SCHEMBL6133366 | 0.84 | BRD9 (0.35) | MAPK14CNR2BRD9ITGA4ITGB7 | |
| SCHEMBL6133253 | 0.81 | MAPK14 (0.40) | MAPK14CNR2BRD9ITGA4ITGB7 | |
| SCHEMBL6133119 | 0.75 | ITGA4 (0.38) | MAPK14CNR2BRD9ITGA4ITGB7 | |
| SCHEMBL25408853 | 0.74 | AR (0.35) | MAPK14CNR2BRD9ITGA4ITGB7 | |
| SCHEMBL2173526 | 0.74 | MAPK1 (0.41) | MAPK14CNR2BRD9GSK3BDYRK1A | |
| SCHEMBL26126269 | 0.73 | CYP2C9 (0.39) | MAPK14CNR2BRD9NTRK1GSK3B | |
| SCHEMBL24255779 | 0.73 | GSK3B (0.37) | MAPK14CNR2BRD9ITGA4ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110072863-B | RIP1 kinase inhibitors and methods of use | 豪夫迈·罗氏有限公司 | 2022-08-30 | — | — | CN | disclosed |