SCHEMBL2884756

SCHEMBL2884756

CC(Br)c1cccc(Br)c1Br

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.41
GABRA1 P14867 4/20 0.36
CYP1A2 P05177 3/20 0.36
GABRB2 P47870 3/20 0.36
CYP3A4 P08684 3/20 0.36
GABRG2 P18507 2/20 0.36
GABRB3 P28472 2/20 0.36
FAAH O00519 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
LMNA P02545 1/20 0.36
HPGD P15428 1/20 0.36
TSHR P16473 1/20 0.36
GABRB1 P18505 1/20 0.36
PTGS1 P23219 1/20 0.36
SLC6A2 P23975 1/20 0.36
HTR2C P28335 1/20 0.36
GABRA5 P31644 1/20 0.36
GABRA3 P34903 1/20 0.36
HTR2B P41595 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6679470 0.83 GABRA1 (0.48) GABRA1CYP1A2GABRB2CYP3A4GABRG2
SCHEMBL29661785 0.83 GABRA1 (0.48) GABRA1CYP1A2GABRB2CYP3A4GABRG2
SCHEMBL5185360 0.80 ALDH1A1 (0.34) CYP1A2ALDH1A1CYP2C19CYP2C9IDO1
SCHEMBL3296582 0.80 HTT (0.43) P2RX7GABRA1CYP1A2GABRB2CYP3A4
SCHEMBL1368986 0.80 HTT (0.43) P2RX7GABRA1CYP1A2GABRB2CYP3A4
SCHEMBL3293339 0.80 HTT (0.43) P2RX7GABRA1CYP1A2GABRB2CYP3A4
SCHEMBL16960570 0.79 GABRA1 (0.34) GABRA1CYP1A2GABRB2CYP3A4GABRG2
SCHEMBL15301961 0.79 GABRA1 (0.34) GABRA1CYP1A2GABRB2CYP3A4GABRG2
SCHEMBL10750207 0.79 HTT (0.36) P2RX7GABRA1CYP1A2GABRB2CYP3A4
SCHEMBL10751510 0.79 GABRA1 (0.39) GABRA1CYP1A2GABRB2CYP3A4GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2010530439-A 2010-09-09 JP claimed
EP-2115059-A1 FLAME RETARDANT COMPOSITION FOR USE IN STYRENICS CHEMTURA CORPORATION (US) 2009-11-11 EP claimed
WO-2008127753-A1 FLAME RETARDANT COMPOSITION FOR USE IN STYRENICS CHEMTURA CORPORATION (US) 2008-10-23 WO claimed
US-20080221239-A1 Flame retardant composition for use in styrenics RECREATIONAL WATER PRODUCTS, INC. 2008-09-11 US claimed
US-4633026-A DEHYDROHALOGENATION OF RING-HALOGENATED ALPHA- OR BETA-BROMOETHYL BENZENES WITH STRONG BASE, POLYOXYETHYLENE GLYCOL CATALYST, AMINE POLYMERIZATION INHIBITOR ETHYL CORPORATION (US) 1986-12-30 US claimed
EP-0159915-A2 Process for making ring-halogenated styrenes and their use YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1985-10-30 EP claimed
US-4292453-A REACTION OF A HALO DERIVATIVE OF BETA-BROMOETHYLBENZENE WITH AQUEOUS ALKALI AND A QUATERNARY PHASE TRANSFER CATALYST MAKHTESHIM CHEMICAL WORKS LTD. (IL) 1981-09-29 US claimed
US-8513346-B2 Flame retardant composition for use in styrenics CHEMTURA CORPORATION (US) 2013-08-20 US disclosed
CN-101652418-B Flame retardant composition for use in styrenics CHEMTURA CORP 2012-12-19 CN disclosed
US-20120184638-A1 Flame Retardant Composition for Use in Styrenics LANXESS SOLUTIONS US INC. 2012-07-19 US disclosed
CN-101652418-A The fire-retardant combination that is used for styrene resin CHEMTURA CORP US 2010-02-17 CN disclosed
US-20080221239-A1 Flame retardant composition for use in styrenics RECREATIONAL WATER PRODUCTS, INC. 2008-09-11 US disclosed
US-4960962-A FORMING MONO-, DI-AND TRIBROMOSTYRENE WITHOUT USING A CATALYST ETHYL CORPORATION (US) 1990-10-02 US disclosed
US-4960962-A FORMING MONO-, DI-AND TRIBROMOSTYRENE WITHOUT USING A CATALYST ETHYL CORPORATION (US) 1990-10-02 US disclosed
US-4686311-A Dehydrohalogenation of haloethyl brominated benzenes ETHYL CORPORATION (US) 1987-08-11 US disclosed
EP-0159915-A2 Process for making ring-halogenated styrenes and their use YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1985-10-30 EP disclosed
US-4423262-A Preparation of dibromostyrene ETHYL CORPORATION (US) 1983-12-27 US disclosed
US-3980722-A Production of bromostyrene, dibromostyrene and alkyl bromides YEDA RESEARCH & DEVELOPMENT CO. LTD. (IL) 1976-09-14 US disclosed
US-3980722-A Production of bromostyrene, dibromostyrene and alkyl bromides YEDA RESEARCH & DEVELOPMENT CO. LTD. (IL) 1976-09-14 US disclosed
US-3867468-A Production of dibromostyrene and alkyl bromide YEDA RES & DEV 1975-02-18 US disclosed