Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL27517314 | 0.85 | CARM1 (0.58) | RENCARM1PRMT6PRMT8TMEM97 | |
| Acetic Acid SCHEMBL27673324 | 0.84 | CARM1 (0.55) | CARM1PRMT6PRMT8MEN1KMT2A | |
| Acetic Acid SCHEMBL27681175 | 0.81 | REN (0.48) | RENBACE1CARM1PRMT6PRMT8 | |
| Acetic Acid SCHEMBL4347586 | 0.80 | REN (0.47) | RENBACE1CARM1PRMT6PRMT8 | |
| Acetic Acid SCHEMBL28005843 | 0.78 | REN (0.42) | RENBACE1CARM1PRMT6PRMT8 | |
| SCHEMBL8507573 | 0.76 | REN (0.47) | RENBACE1CARM1PRMT6PRMT8 | |
| Acetic Acid SCHEMBL14343057 | 0.76 | KMT2A (0.59) | MEN1KMT2ASIGMAR1 | |
| Acetic Acid SCHEMBL29170764 | 0.76 | KMT2A (0.59) | MEN1KMT2ASIGMAR1 | |
| SCHEMBL11293490 | 0.76 | CARM1 (0.47) | RENCARM1PRMT6PRMT8 | |
| Acetic Acid SCHEMBL8540399 | 0.76 | MEN1 (0.57) | MEN1KMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109796524-A | Desmoglein2 (DSG2) conjugated protein and application thereof | 华盛顿大学商业化中心 | 2019-05-24 | — | — | CN | disclosed |
| CN-105008535-B | Desmoglein 2(DSG2) binding proteins and uses thereof | 华盛顿大学商业化中心 | 2018-10-16 | — | — | CN | disclosed |
| CN-107041146-A | Desmoglein 2(DSG2) binding proteins and uses thereof | 华盛顿大学商业化中心 | 2017-08-11 | — | — | CN | disclosed |