Phosphine

Phosphine

SCHEMBL28847993

CCCCCc1ccc2c(c1)C(=O)c1ccccc1C2=O.P

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.64
LMNA P02545 2/20 0.64
MAPK1 P28482 2/20 0.64
RAB9A P51151 2/20 0.64
SMN1; SMN2 Q16637 2/20 0.64
ALDH1A1 P00352 1/20 0.64
MAPT P10636 1/20 0.64
L3MBTL1 Q9Y468 1/20 0.64
GPR3 P46089 1/20 0.55
PTPN1 P18031 1/20 0.50
ELANE P08246 2/20 0.46
LPL P06858 2/20 0.45
LIPG Q9Y5X9 2/20 0.45
CASP3 P42574 1/20 0.45
ATM Q13315 1/20 0.45
SENP8 Q96LD8 1/20 0.45
SENP7 Q9BQF6 1/20 0.45
SENP6 Q9GZR1 1/20 0.45
MAOA P21397 1/20 0.44
MAOB P27338 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL37031 0.98 NPC1 (0.66) NPC1LMNAMAPK1RAB9ASMN1; SMN2
SCHEMBL29531152 0.98 NPC1 (0.66) NPC1LMNAMAPK1RAB9ASMN1; SMN2
SCHEMBL28232430 0.97 NPC1 (0.64) NPC1LMNAMAPK1RAB9ASMN1; SMN2
SCHEMBL918609 0.97 NPC1 (0.64) NPC1LMNAMAPK1RAB9ASMN1; SMN2
SCHEMBL9062730 0.97 NPC1 (0.64) NPC1LMNAMAPK1RAB9ASMN1; SMN2
SCHEMBL526408 0.93 NPC1 (0.68) NPC1LMNAMAPK1RAB9ASMN1; SMN2
SCHEMBL29734325 0.93 NPC1 (0.68) NPC1LMNAMAPK1RAB9ASMN1; SMN2
SCHEMBL9771937 0.92 GPR3 (0.57) NPC1LMNAMAPK1RAB9ASMN1; SMN2
SCHEMBL8670796 0.92 NPC1 (0.66) NPC1LMNAMAPK1RAB9ASMN1; SMN2
Thiophene SCHEMBL28324548 0.90 NPC1 (0.55) NPC1LMNAMAPK1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107073816-A Stereolithographic process and composition DWS有限公司 2017-08-18 CN disclosed