Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.66 |
| ▸ | RAB9A | P51151 | 5/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | GPR3 | P46089 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL526408 | 0.98 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL29734325 | 0.98 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL8669846 | 0.97 | SMN1; SMN2 (0.61) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL37031 | 0.93 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL29531152 | 0.93 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| Phosphine SCHEMBL28847993 | 0.92 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL28232430 | 0.92 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL918609 | 0.92 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL9062730 | 0.92 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL9771937 | 0.90 | GPR3 (0.57) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-04-27 | — | — | US | disclosed |
| US-11545634-B2 | Heterocyclic spiro compounds | MERCK PATENT GMBH (DE) | 2023-01-03 | — | — | US | disclosed |
| US-10777750-B2 | Heterocyclic spiro compounds | BASF SE (DE) | 2020-09-15 | — | — | US | disclosed |
| US-20200266364-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2020-08-20 | — | — | US | disclosed |
| US-10665790-B2 | Materials for electronic devices | MERCK PATENT GMBH (DE) | 2020-05-26 | — | — | US | disclosed |
| US-20170301865-A1 | MATERIALS FOR ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
| EP-0886182-A1 | Positive photoresist composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10665790-B2 | Materials for electronic devices | SDHB, SDHA, ETFB | NPC1 3354/4885RAB9A 2932/4885SMN1; SMN2 1775/4885 |
| US-11545634-B2 | Heterocyclic spiro compounds | NES, KCNC1, HCN4 | NPC1 2116/4885RAB9A 1935/4885SMN1; SMN2 3900/4885 |
| US-20200266364-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | NPC1 2116/4885RAB9A 1935/4885SMN1; SMN2 3900/4885 |
| US-20170301865-A1 | MATERIALS FOR ELECTRONIC DEVICES | SDHB, SDHA, ETFB | NPC1 3354/4885RAB9A 2932/4885SMN1; SMN2 1775/4885 |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | NPC1 2116/4885RAB9A 1935/4885SMN1; SMN2 3900/4885 |
| US-10777750-B2 | Heterocyclic spiro compounds | NES, KCNC1, HCN4 | NPC1 2116/4885RAB9A 1935/4885SMN1; SMN2 3900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.