Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | S100A4 | P26447 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2209087 | 0.86 | ALDH1A1 (0.47) | SIRT6MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL521342 | 0.85 | MAPT (0.50) | MAPTALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL3315189 | 0.85 | MAPT (0.54) | MAPTALDH1A1LMNAMAPK1MEN1 | |
| SCHEMBL16513957 | 0.84 | MAPT (0.56) | SIRT6MAPTALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL29847859 | 0.84 | MAPT (0.56) | SIRT6MAPTALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL3346768 | 0.83 | ALDH1A1 (0.44) | SIRT6MAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL30464721 | 0.82 | MAPT (0.54) | SIRT6MAPTALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL22471527 | 0.82 | MAPT (0.54) | SIRT6MAPTALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL20367087 | 0.81 | MAPT (0.45) | MAPTALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL521625 | 0.81 | MAPT (0.46) | MAPTALDH1A1LMNAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106916112-B | Pyrimidine derivative, preparation method and medical application thereof | 四川海思科制药有限公司 | 2019-12-20 | — | — | CN | disclosed |
| CN-106916112-A | Pyrimidine derivatives and preparation method thereof and in application pharmaceutically | 四川海思科制药有限公司 | 2017-07-04 | — | — | CN | disclosed |