Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346195 | 0.89 | MAPT (0.41) | ALDH1A1MAPTGAALMNARECQL | |
| SCHEMBL3345903 | 0.87 | MAPT (0.43) | ALDH1A1MAPTGAALMNARECQL | |
| SCHEMBL28848356 | 0.83 | SIRT6 (0.53) | ALDH1A1MAPTLMNAKDM4ESIRT6 | |
| SCHEMBL521624 | 0.82 | MAPT (0.46) | ALDH1A1MAPTGAALMNARECQL | |
| SCHEMBL521625 | 0.82 | MAPT (0.46) | ALDH1A1MAPTGAALMNARECQL | |
| SCHEMBL3345933 | 0.81 | HTR1A (0.36) | ALDH1A1MAPTGAAKDM4EMAPK1 | |
| SCHEMBL2209087 | 0.80 | ALDH1A1 (0.47) | ALDH1A1MAPTGAALMNARECQL | |
| SCHEMBL521342 | 0.79 | MAPT (0.50) | ALDH1A1MAPTGAALMNARECQL | |
| SCHEMBL3315189 | 0.79 | MAPT (0.54) | ALDH1A1MAPTGAALMNARECQL | |
| SCHEMBL3345297 | 0.78 | MAPT (0.54) | ALDH1A1MAPTGAALMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |