Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP8 | P40818 | 6/20 | 0.58 |
| ▸ | PARP1 | P09874 | 4/20 | 0.57 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | CDK9 | P50750 | 2/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | CBS | P35520 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CCNH | P51946 | 1/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22667392 | 0.87 | CCNT1 (0.64) | USP8PARP1PARP2CCNT1CCNA2 | |
| SCHEMBL28848497 | 0.83 | USP8 (0.71) | USP8PARP1PARP2CCNT1CCNA2 | |
| SCHEMBL22667393 | 0.78 | CYP1A1 (0.56) | USP8CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL29877108 | 0.78 | CYP1A1 (0.56) | USP8CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL28848518 | 0.76 | USP8 (0.70) | USP8PARP1PARP2CCNT1CCNA2 | |
| SCHEMBL28953790 | 0.74 | USP8 (1.00) | USP8CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL22667394 | 0.73 | CCNT1 (0.84) | USP8PARP1PARP2CCNT1CCNA2 | |
| SCHEMBL22667441 | 0.72 | CCNT1 (0.83) | USP8PARP1PARP2CCNT1CCNA2 | |
| SCHEMBL28848509 | 0.72 | CDK4 (0.82) | PARP1PARP2CCNT1CCNA2CDK2 | |
| Tetramethylammonium Ion SCHEMBL28848523 | 0.71 | CBS (0.50) | USP8PARP1PARP2CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114957182-B | USP8 inhibitor containing flavone skeleton structure and application thereof | 中国药科大学 | 2024-03-15 | — | — | CN | disclosed |
| CN-114957182-A | USP8 inhibitor containing flavone skeleton structure and application thereof | 中国药科大学 | 2022-08-30 | — | — | CN | disclosed |