Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acrylic Acid Methyl Ester. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid Methyl Ester SCHEMBL21715435 | 0.97 | HCAR2 (0.50) | HCAR2KEAP1NFE2L2LMNATSHR | |
| Acrylic Acid Methyl Ester SCHEMBL29240015 | 0.97 | HCAR2 (0.50) | HCAR2KEAP1NFE2L2LMNATSHR | |
| Acrylic Acid Methyl Ester SCHEMBL28171454 | 0.94 | HCAR2 (0.48) | HCAR2KEAP1NFE2L2LMNATSHR | |
| Acrylic Acid Methyl Ester SCHEMBL28163789 | 0.94 | HCAR2 (0.48) | HCAR2KEAP1NFE2L2LMNATSHR | |
| Acrylic Acid Methyl Ester SCHEMBL27711425 | 0.94 | HCAR2 (0.53) | HCAR2KEAP1NFE2L2LMNATSHR | |
| Acrylic Acid Methyl Ester SCHEMBL43991 | 0.94 | — | — | |
| Acrylic Acid Methyl Ester SCHEMBL14892886 | 0.94 | — | — | |
| Acrylic Acid Methyl Ester SCHEMBL7643400 | 0.94 | HCAR2 (0.53) | HCAR2KEAP1NFE2L2LMNATSHR | |
| Acrylic Acid Methyl Ester SCHEMBL9182225 | 0.92 | LMNA (0.53) | HCAR2KEAP1NFE2L2LMNATSHR | |
| Acrylic Acid Methyl Ester SCHEMBL5156014 | 0.92 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107001682-A | The manufacture method of perforated membrane | 住友化学株式会社 | 2017-08-01 | — | — | CN | disclosed |