Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.38 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 2/20 | 0.35 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537136 | 0.94 | CYP2D6 (0.42) | CYP2D6TSHRCYP2C19HIF1AGRM2 | |
| SCHEMBL28796367 | 0.91 | TSHR (0.41) | CYP2D6TSHRCYP2C19HIF1ALMNA | |
| SCHEMBL1110756 | 0.84 | AMPD2 (0.36) | CYP2D6TSHRCYP2C19HIF1ALMNA | |
| SCHEMBL16415100 | 0.83 | CYP2D6 (0.38) | CYP2D6TSHRCYP2C19HIF1AGRM2 | |
| SCHEMBL536364 | 0.81 | CYP1A2 (0.41) | LMNAALKBH5SUCNR1EGLN1GRM2 | |
| SCHEMBL3667247 | 0.80 | CYP2D6 (0.35) | CYP2D6TSHRCYP2C19HIF1AGRM2 | |
| SCHEMBL8009657 | 0.78 | CYP2D6 (0.41) | CYP2D6TSHRCYP2C19HIF1AGRM2 | |
| SCHEMBL536369 | 0.78 | LMNA (0.39) | TSHRLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL10011213 | 0.77 | CYP2D6 (0.33) | CYP2D6TSHRCYP2C19HIF1AALDH1A1 | |
| SCHEMBL2230547 | 0.76 | LMNA (0.42) | TSHRLMNAALDH1A1ADRA1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115135681-A | Propylene-based polymer composition with high molecular weight tail | 埃克森美孚化学专利公司 | 2022-09-30 | — | — | CN | disclosed |