AMPD2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL23124104	0.51	15/20
SCHEMBL29789663	0.51	15/20
SCHEMBL13503917	0.52	14/20
SCHEMBL27979486	0.51	12/20
SCHEMBL13681455	0.52	11/20
SCHEMBL23123725	0.52	11/20
SCHEMBL29790009	0.52	11/20
SCHEMBL20915109	0.57	10/20
SCHEMBL15718613	0.54	9/20
SCHEMBL13415334	0.51	9/20
SCHEMBL11007123	0.44	9/20
SCHEMBL26932396	0.51	8/20
SCHEMBL31599737	0.44	8/20
SCHEMBL31415088	0.52	7/20
SCHEMBL11784247	0.50	7/20
SCHEMBL28577145	0.45	7/20
SCHEMBL11668979	0.45	7/20
SCHEMBL11008168	0.41	7/20
Coformycin (SCHEMBL11184406)	0.51	6/20
Coformycin (SCHEMBL14031897)	0.51	6/20

Clinical trials — most relevant to AMPD2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Genomic Outcomes of Metformin	PHASE4	COMPLETED
Metformin Use to Reduce Disparities in Newly Diagnosed Breast Cancer	PHASE4	WITHDRAWN
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity	PHASE4	COMPLETED
Acelarin First Line Randomised Pancreatic Study	PHASE2/PHASE3	SUSPENDED
Vitamin D Status in Patients With Severe Sepsis	PHASE3	WITHDRAWN
The Effects of GLP-1 in Maturity-Onset Diabetes of The Young (MODY)	PHASE2/PHASE3	COMPLETED
MND-ADA Transduction of CD34+ Cells From Children With ADA-SCID	PHASE2	COMPLETED
Effects of Vitamin B3 in Patients With Ataxia Telangiectasia	PHASE2	COMPLETED
Metformin for Fibromyalgia Symptoms (INFORM Trial)	PHASE2	RECRUITING
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
University of California, San Diego (UCSD) Suramin Autism Treatment-1 (SAT1) Trial	PHASE1/PHASE2	COMPLETED
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia	PHASE1/PHASE2	COMPLETED
AMP-224, a PD-1 Inhibitor, With Stereotactic Body Radiation Therapy in Metastatic Colorectal Cancer	PHASE1	COMPLETED
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.	PHASE1	COMPLETED
A Phase I Trial of SHR3162 in Subjects With Advanced Solid Tumors	PHASE1	COMPLETED
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer	EARLY_PHASE1	COMPLETED
Effects of Pimecrolimus on Skin Biopsy Ex-plants From Patients With Atopic Dermatitis	nan	COMPLETED
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia	nan	COMPLETED
Evaluation of Adenosine Deaminase (ADA) Enzyme Deficiency in Patients With Lymphopenia and/or Elevated Immunoglobulin E	nan	UNKNOWN
ADAR1 Expression Level in Rectal Cancer	nan	RECRUITING
Epigenetics, DNA Methylation Patterns and Periodontal Disease	nan	COMPLETED
Observational Study Evaluating the Prevalence of Enzyme Deficiency in Pulmonology Clinics (ADA)	nan	UNKNOWN
Prevalence of Adenosine Deaminase (ADA) Enzyme Deficiency Disease in Adult Patients With Pulmonary Alveolar Proteinosis	nan	UNKNOWN
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
Study of Selected X-Linked Disorders: Aicardi Syndrome	nan	RECRUITING
Evaluation the Topical Apremilast Nanoformulation in Treatment of Localized Plaque Psoriasis	nan	NOT_YET_RECRUITING
Leveraging Artificial Intelligence and Multi-Omics Data to Predict Opioid Addiction	nan	ACTIVE_NOT_RECRUITING
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages	nan	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a AMPD2 binder may also engage these)

Protein	Name	Similarity
Q9DBT5	—	1.000	Q9DBT5 →
Q02356	—	1.000	Q02356 →
O08739	—	0.999	O08739 →
O09178	—	0.996	O09178 →
P10759	—	0.993	P10759 →
AMPD3	AMP deaminase 3	0.992	landscape →
AMPD1	AMP deaminase 1	0.991	landscape →
A7Z050	—	0.991	A7Z050 →
Q6PFW1	—	0.989	Q6PFW1 →
Q3V1D3	—	0.987	Q3V1D3 →
P0C644	—	0.987	P0C644 →
Q5XHF8	—	0.986	Q5XHF8 →
F4J8C6	—	0.986	F4J8C6 →
P54310	—	0.986	P54310 →
Q5RDF1	—	0.986	Q5RDF1 →
O00562	—	0.985	O00562 →
Q9Z0S8	—	0.985	Q9Z0S8 →
O80452	—	0.985	O80452 →
Q68J42	—	0.984	Q68J42 →
Q84WW3	—	0.984	Q84WW3 →
P50998	—	0.984	P50998 →
A2ARP1	—	0.984	A2ARP1 →
Q499S9	—	0.984	Q499S9 →
Q58CP9	—	0.984	Q58CP9 →
A9L8T6	—	0.984	A9L8T6 →
O35954	—	0.984	O35954 →
Q6GMF8	—	0.984	Q6GMF8 →
Q84NP7	—	0.984	Q84NP7 →
Q6PIX5	—	0.983	Q6PIX5 →
Q6ZQB6	—	0.983	Q6ZQB6 →