Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.52 |
| ▸ | JAK2 | O60674 | 6/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | TEC | P42680 | 1/20 | 0.41 |
| ▸ | TXK | P42681 | 1/20 | 0.41 |
| ▸ | BMX | P51813 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16320377 | 0.85 | BTK (0.54) | BTKJAK2 | |
| SCHEMBL28166026 | 0.78 | BTK (0.52) | BTK | |
| SCHEMBL28851455 | 0.76 | BTK (0.39) | BTKJAK2CDK2 | |
| SCHEMBL28166036 | 0.76 | BTK (0.50) | BTKJAK2 | |
| SCHEMBL122351 | 0.76 | BTK (0.63) | BTKJAK2AURKALCKLYN | |
| SCHEMBL149527 | 0.75 | BTK (0.47) | BTKJAK2 | |
| SCHEMBL148464 | 0.72 | BTK (0.43) | BTKJAK2AURKALCKLYN | |
| SCHEMBL18976381 | 0.71 | BTK (0.43) | BTKJAK2 | |
| SCHEMBL21917299 | 0.70 | BTK (0.80) | BTKJAK2 | |
| SCHEMBL28054157 | 0.69 | PIM1 (0.46) | BTKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105358546-B | The tetrahydro carbazole being substituted and carbazole carboxamide compounds useful as kinase inhibitor | 百时美施贵宝公司 | 2017-10-31 | — | — | CN | disclosed |