Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.45 |
| ▸ | CCNC | P24863 | 2/20 | 0.44 |
| ▸ | CDK8 | P49336 | 2/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20392628 | 0.84 | SLC22A12 (0.46) | SLC22A12CCNCCDK8NCF1HTT | |
| SCHEMBL20392611 | 0.82 | SLC22A12 (0.53) | SLC22A12CCNCCDK8NCF1HTT | |
| SCHEMBL20392630 | 0.82 | SLC22A12 (0.48) | SLC22A12CCNCCDK8NCF1HTT | |
| SCHEMBL22122314 | 0.79 | LMNA (0.48) | SLC22A12CCNCCDK8NCF1HTT | |
| SCHEMBL3817375 | 0.75 | LOXL2 (0.64) | NCF1LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL29896761 | 0.75 | SLC22A12 (0.51) | SLC22A12CCNCCDK8NCF1HTT | |
| SCHEMBL14690611 | 0.75 | SLC22A12 (0.51) | SLC22A12CCNCCDK8NCF1HTT | |
| SCHEMBL22122307 | 0.72 | SLC22A12 (0.47) | SLC22A12CCNCCDK8HTTALDH1A1 | |
| SCHEMBL16247955 | 0.72 | SLC22A12 (0.49) | SLC22A12CCNCCDK8NCF1HTT | |
| SCHEMBL741042 | 0.72 | SLC22A12 (0.53) | SLC22A12CCNCCDK8NCF1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107223123-A | BCL-XL inhibitory compound having low cell permeability and antibody drug conjugate including the same | 艾伯维公司 | 2017-09-29 | — | — | CN | disclosed |
| CN-107207553-A | BCL-XL-inhibitory compounds and antibody drug conjugates including the same | 艾伯维公司 | 2017-09-26 | — | — | CN | disclosed |